UTILITY OF THE INSULIN CURVE IN ADDITION TO OGTT IN DETECTING HYPERINSULINEMIA IN PATIENTS WITH PCOS

The purpose of this study is to investigate the utility insulin curve with Oral Glucose Tolerance Test (OGTT) in identifying hyperinsulinemia Polycystic Ovarian Syndrome (PCOS) patients. Further, identify clinical characteristics PCOS subpopulation that has a normal OGTT, but presence by curve, compared patients without evidence hyperinsulinemia. A retrospective cross-sectional was performed on all seen during period January 2018 October at large, academic-affiliated, urban fertility clinic, Texas Children’s Hospital Family Fertility Center. Descriptive and demographic variables were gathered, including labs ordered time diagnosis. inclusion criteria included aged greater than 18, diagnosed 2003 Rotterdam Consensus Criteria. total 227 met criteria. Of these patients, 107 had HgbA1c three hour OGTT results. Chi-square analysis statistical test used for significance testing. results, 49.5% specificity sensitivity patient’s 2-hour results as an indicator 98% 18.8%, respectively. 100% 15%, acanthosis nigricans 47% 87%, There no difference acne, hirsutism, irregular periods, or polycystic ovaries between those negative positive (p=.29, p=.76, p=.27, p=.45). However, there significant cohorts based presence/absence weight versus BMI 25 (p<.01, p<.05). Given if healthcare providers are utilizing only metabolic screening tests impaired glucose tolerance PCOS, then will be miss identification. Detecting allow discuss more aggressive management options, such metformin, higher risk developing overt gestational diabetes type II diabetes.